PGT-A is a form of preimplantation genetic test to check for chromosomes number abnormalities in an embryo (aneuploidy), previously it is known as Preimplantation Genetic Screening (PGS). PGT-A or Preimplantation Genetic Testing for Aneuploidies are a form of screening that can be utilized in In-Vitro Fertilisation (IVF) cycle or test-tube baby program. This method can be used to analyze the chromosome of an embryo before transferring it to the womb.
PGT-A will provide an information about the number of chromosomes found in each embryo. The objective of PGT-A is to increase the chance of successful pregnancy, reduce miscarriage risk, and risk of having a child with chromosomal abnormalities. This test was done by extracting cell biopsy from an embryo (trophoectoderm) and analyzed by using Next Generation Sequencing technology (Illumina platform, USA). The test result will be available in 14 working days.
Normal chromosomes (Euploid) are 46XY / 46XX from an embryo make up the basis of human genetics. PGT-A allow us to check the 23 pairs of chromosomes including X and Y chromosomes in each embryo which have a higher chance of success can be chosen for embryo transfer into the womb.